Association of FSHβ Gene (-211 G>T) Polymorphism with Infertility in Iraqi women in Maysan Governorate
DOI:
https://doi.org/10.63359/d8bcyj16Keywords:
FSHβ gene, infertility women, SNP, polymorphismAbstract
Background: Female infertility is a multifactorial condition influenced by genetic factors, particularly genes involved in the hypothalamic–pituitary–ovarian axis. The follicle-stimulating hormone beta (FSHβ) gene plays a crucial role in follicular development and reproductive function.
Methods: This case–control study included 60 infertile women and 30 healthy controls from Maysan, Iraq. Genomic DNA was extracted and analyzed using PCR and DNA sequencing to detect the -211 G>T polymorphism in the promoter region of the FSHβ gene.
Results: A single nucleotide polymorphism (-211 G>T) was identified in the promoter region. The genotype frequencies (GG, GT, TT) in infertile women were 87.5%, 6.25%, and 6.25%, respectively. The T allele frequency was higher in infertile women compared to controls. A statistically significant association was observed for the TT genotype (P < 0.05).
Conclusion: The -211 G>T polymorphism in the FSHβ gene may be associated with infertility in Iraqi women and could serve as a potential genetic marker for reproductive disorders.
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